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St. Johns Wort

Some research shows St. John’s wort can help treat depression and other medical conditions.

A 2017 analysis of 27 studies determined that St. John’s wort had similar effects on mild to moderate depression as antidepressants. Those researchers also noted that fewer people stopped taking St. John’s wort, compared to antidepressants.

Another study indicated St. John’s wort can be effective in treating wounds, bruises, burns, and sores.


  • Increased sensitivity to the sun, especially if you are fair-skinned and taking large doses
  • Increase in blood pressure
  • Do not take St. John's wort during pregnancy or while you are breastfeeding.

St. John’s wort has been associated with very serious and potentially dangerous interactions with many common drugs. St. John’s wort can weaken how well other drugs work, including antidepressants, birth control pills, cyclosporine (an anti-rejection drug), digoxin (a heart drug), HIV drugs, cancer medications, and blood thinners such as Coumadin.